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2012 IEEE Symposium on Biological Data Visualization (BioVis)

DOI: 10.1109/biovis.2012.6378598

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Uncertainty-aware visual analysis of biochemical reaction networks.

This paper is available in a repository.
This paper is available in a repository.

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Abstract

We present a visual analytics system that supports an uncertainty-aware analysis of static and dynamic attributes of biochemical reac-tion networks (BRNs). These are often described by mathematical models, such as ordinary differential equations (ODEs), which en-able the integration of a multitude of different data and data types using parameter estimation. Due to the limited amount of data, pa-rameter estimation does not necessarily yield a single point in pa-rameter space and many attributes of the model remain uncertain. Our system visualizes the model as a graph, where the statistics of the attributes are mapped to the color of edges and vertices. The graph view is combined with several linked views such as lineplots, scatterplots, and correlation matrices, to support the identification of uncertainties and the analysis of their mutual dependencies as well as their time dependencies. To assess the utility of the individ-ual visualization approaches and multiple linked views, a qualita-tive user study with domain experts was performed. We found that all users were able to process analysis tasks using our system.