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Oxford University Press, The American Journal of Clinical Nutrition, 3(87), p. 567-576, 2008

DOI: 10.1093/ajcn/87.3.567

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Effects of weight loss from a very-low-carbohydrate diet on endothelial function and markers of cardiovascular disease risk in subjects with abdominal obesity

Journal article published in 2008 by Keogh Jb, Clifton Pm, Jennifer B. Keogh, Grant D. Brinkworth ORCID, Brinkworth Gd, Manny Noakes, Damien P. Belobrajdic, Belobrajdic Dp, Jonathan D. Buckley, Buckley Jd, Peter M. Clifton ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

BACKGROUND: The effects of a very-low-carbohydrate, high-saturated-fat weight-loss diet (LC) on brachial artery flow-mediated dilatation (FMD) and markers of endothelial function are unknown. OBJECTIVE: The effect of an LC on markers of endothelial function and cardiovascular disease (CVD) risk was compared with that of an isocaloric high-carbohydrate, low-saturated-fat diet (HC). DESIGN: FMD and markers of endothelial function (n = 70) and CVD risk were measured before and after 8 wk of weight loss. Ninety-nine subjects aged 50.0 +/- 8.3 y with a body mass index (in kg/m2) of 33.7 +/- 4.1 completed the study. RESULTS: Mean (+/-SD) FMD did not change significantly (P = 0.55) with either diet. Pulse wave velocity improved with both diets (P