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CSIRO Publishing, Australian Journal of Chemistry, 3(64), p. 253, 2011

DOI: 10.1071/ch10453

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Uptake and distribution of a platinum(II)-carborane complex within a tumour cell using synchrotron XRF imaging

Journal article published in 2011 by Ellen L. Crossley, Jade B. Aitken, Stefan Vogt ORCID, Hugh H. Harris ORCID, Louis M. Rendina
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

Treatment of A549 human lung carcinoma cells with a DNA metallointercalator complex containing a PtII-terpy (terpy = 2,2′:6′,2′′-terpyridine) unit linked to a functionalized closo-carborane cage results in the uptake of the complex within the cells, as determined by synchrotron X-ray fluorescence (XRF) imaging. Although a significant cellular uptake of Pt existed, there was no significant accumulation of the element within the cell nuclei. Other statistically significant changes from the XRF data included an increase in Cl, K, and Cu and a decrease in Fe within the treated cells. ; Ellen L. Crossley, Jade B. Aitken, Stefan Vogt, Hugh H. Harris and Louis M. Rendina