Published in
Lippincott, Williams & Wilkins, The American Journal of Gastroenterology, 7(106), p. 1281-1289, 2011
DOI: 10.1038/ajg.2011.85
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Differences in inflammatory bowel disease phenotype between South Asians and Northern Europeans living in North West London, UK
,
Ian McNeil,
Huw J. W. Thomas,
Julian P. Teare,
Ailsa L. Hart,
Maxton C. L. Pitcher,
Julian R. F. Walters ,
Sara E. Marshall,
Timothy R. Orchard
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Abstract
OBJECTIVES: The incidence and prevalence of inflammatory bowel disease (IBD) is increasing throughout Asia. Since the 1950s, there has been substantial migration from South Asia (India, Pakistan, and Bangladesh) to the United Kingdom. The aim of this study was to define the clinical phenotype of IBD in UK South Asians living in North West London, and to compare the results with a white Northern European IBD cohort. METHODS: The phenotypic details of 367 South Asian IBD patients (273 ulcerative colitis (UC) and 94 Crohn's disease (CD)), undergoing active follow-up in five North West London hospitals, were compared with those of 403 consecutively collected white Northern European IBD patients (188 UC and 215 CD). RESULTS: The phenotype of IBD differed significantly between the two populations. 63.0% of South Asian UC patients had extensive colitis compared with 42.5% of the Northern European cohort (P