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Springer, Diabetologia, 5(52), p. 891-900, 2009

DOI: 10.1007/s00125-009-1294-y

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Potential role of TBC1D4 in enhanced post-exercise insulin action in human skeletal muscle

Journal article published in 2009 by J. T. Treebak ORCID, C. Frosig, C. Pehmoller, S. Chen, S. J. Maarbjerg, N. Brandt, C. MacKintosh ORCID, J. R. Zierath, D. G. Hardie, B. Kiens ORCID, Richter Ea, E. A. Richter, H. Pilegaard, J. F. P. Wojtaszewski ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

TBC1 domain family, member 4 (TBC1D4; also known as AS160) is a cellular signalling intermediate to glucose transport regulated by insulin-dependent and -independent mechanisms. Skeletal muscle insulin sensitivity is increased after acute exercise by an unknown mechanism that does not involve modulation at proximal insulin signalling intermediates. We hypothesised that signalling through TBC1D4 is involved in this effect of exercise as it is a common signalling element for insulin and exercise. Insulin-regulated glucose metabolism was evaluated in 12 healthy moderately trained young men 4 h after one-legged exercise at basal and during a euglycaemic-hyperinsulinaemic clamp. Vastus lateralis biopsies were taken before and immediately after the clamp. Insulin stimulation increased glucose uptake in both legs, with greater effects (similar to 80%, p