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BioMed Central, BMC Cancer, 1(14), 2014

DOI: 10.1186/1471-2407-14-957

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MICA/B and ULBP1 NKG2D ligands are independent predictors of good prognosis in cervical cancer

Journal article published in 2014 by Hanbyoul Cho, Joon-Yong Chung ORCID, Sunghoon Kim, Till Braunschweig ORCID, Tae Heung Kang, Jennie Kim, Eun Joo Chung, Stephen M. Hewitt ORCID, Jae-Hoon Kim
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background NKG2D (natural killer group 2, member D) is thought to play an important role in mediating the activation of anticancer immune response. Expression of NKG2D ligands (NKG2DLs) is pronounced in malignancies and the heterogeneity of NKG2DL expression remains unclear. Here, we investigate the expression and clinical significance of NKG2DLs in cervical cancer. Methods Immunohistochemical analyses of MICA/B, ULBP1, ULBP2, ULBP3, RAET1E, and RAET1G were performed using tissue microarray analysis of 200 cervical cancers, 327 high-grade cervical intraepithelial neoplasias (CINs), 99 low-grade CINs, and 541 matched nonadjacent normal cervical epithelial tissues and compared the data with clinicopathologic variables, including the survival of cervical cancer patients. Results MICA/B, ULBP1, and RAET1E expression was higher in cervical cancer than in low-grade CIN ( p