Published in

Elsevier, Journal of Hepatology, 2(50), p. 342-350, 2009

DOI: 10.1016/j.jhep.2008.08.025

Links

Tools

Export citation

Search in Google Scholar

High-fat nutrition reduces hepatic damage following exposure to bacterial DNA and hemorrhagic shock

Journal article published in 2009 by Misha Dp P. Luyer, Joep Pm M. Derikx ORCID, Rudi Beyaert ORCID, M'hamed Hadfoune, Toin H. van Kuppevelt, A. H. M. S. M. van Kuppevelt, Cornelis Hc C. Dejong, Erik Heineman, Wim A. Buurman, Jan Willem M. Greve
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Background/Aims: Bacterial infection combined with hypotension results in exacerbation of the inflammatory response with release of interferon (IFN) gamma. This excessive inflammation may lead to development of hepatic damage and liver failure. This study investigates the effect of dietary lipids on release of IFN-gamma and development of hepatic damage following exposure to synthetic bacterial DNA (CpG-ODN) and hemorrhagic shock. Methods: Rats were exposed to CpG-ODN 18 h before hemorrhagic shock. Samples were taken 4 h following shock. High-fat nutrition was administered at 18 h, 2 h and 45 min before induction of shock. Results: Enteral high-fat strongly reduced circulating IFN-gamma (0.2 ng/ml, P