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Elsevier, Nuclear Medicine and Biology, 6(40), p. 831-840

DOI: 10.1016/j.nucmedbio.2013.05.004

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Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG

Journal article published in 2013 by Sara Belloli ORCID, Andrea Brioschi, Letterio Salvatore Politi, Francesca Ronchetti, Sara Calderoni, Isabella Raccagni, Antonella Pagani, Cristina Monterisi, Francesco Zenga, Gianpaolo Zara, Ferruccio Fazio, Alessandro Mauro, Rosa Maria Moresco
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

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Abstract

The prognosis of malignant gliomas remains largely unsatisfactory for the intrinsic characteristics of the pathology and for the delayed diagnosis. Multimodal imaging based on PET and MRI may assess the dynamics of disease onset and progression allowing the validation of preclinical models of glioblastoma multiforme (GBM). The aim of this study was the characterization of a syngeneic rat model of GBM using combined in vivo imaging and immunohistochemistry.