Adaptation of media resources is an emerging field due to the growing amount of multimedia content on the one hand and an increasing diversity in usage environments on the other hand. Furthermore, to deal with a plethora of coding and metadata formats, format-independent adaptation systems are important. In this paper, we present a new format-independent adaptation system. The proposed adaptation system relies on a model that takes into account the structural metadata, semantic metadata, and scalability information of media bitstreams. The model is implemented using the web ontology language. Existing coding formats are mapped to the structural part of the model, while existing metadata standards can be linked to the semantic part of the model. Our new adaptation technique, which is called RDF-driven content adaptation, is based on executing SPARQL Protocol and RDF Query Language queries over instances of the model for media bitstreams. Using different criteria, RDF-driven content adaptation is compared to other adaptation techniques. Next to real-time execution times, RDF-driven content adaptation provides a high abstraction level for the definition of adaptations and allows a seamless integration with existing semantic metadata standards.