Springer Nature [academic journals on nature.com], Genes and Immunity, 4(14), p. 268-270, 2013
DOI: 10.1038/gene.2013.8
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Haplotypes spanning the tumor necrosis factor (TNF) gene block in the central major histocompatibility complex were defined in a Southern African population using 31 single-nucleotide polymorphisms. Twenty haplotypes accounted for 91.8% of the cohort. The haplotypes matched those described previously in Caucasian and Asian populations, supporting the hypothesis that TNF block haplotypes are ancient and highly conserved. They are presented here as a tool for disease-association studies.Genes and Immunity advance online publication, 14 March 2013; doi:10.1038/gene.2013.8.