Published in

Nature Research, Nature Genetics, 2(41), p. 166-167, 2009

DOI: 10.1038/ng.308

Links

Tools

Export citation

Search in Google Scholar

System-wide molecular evidence for phenotypic buffering in Arabidopsis

Journal article published in 2009 by Jingyuan Fu, Jjb Keurentjes, Harro Bouwmeester, Twan America, Fwa Verstappen, Jane L. Ward, Michael H. Beale, Ric C. H. de Vos, Rch De Vos, Martijn Dijkstra, Richard A. Scheltema, Frank Johannes, Maarten Koornneef, Dick Vreugdenhil, Rainer Breitling ORCID and other authors.
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We profiled 162 lines of Arabidopsis for variation in transcript, protein and metabolite abundance using mRNA microarrays, two-dimensional polyacrylamide gel electrophoresis, gas chromatography time-of-flight mass spectrometry, liquid chromatography quadrupole time-of-flight mass spectrometry, and proton nuclear magnetic resonance. We added all publicly available phenotypic data from the same lines and mapped quantitative trait loci (QTL) for 40,580 molecular and 139 phenotypic traits. We found six QTL hot spots with major, system-wide effects, suggesting there are six breakpoints in a system otherwise buffered against many of the 500,000 SNPs. ?? 2009 Nature America, Inc. All rights reserved.