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Transmission analysis of candidate genes for nonsyndromic oral clefts in Brazilian parent-child triads with recurrence

Journal article published in 2006 by Silva,Aline Lourenço Da, Aline Loureno̧ da Silva, Lucilene Arilho Ribeiro, Ribeiro,Lucilene Arilho, Margaret E. Cooper, Cooper,Margaret E., Marazita,Mary L., Mary L. Marazita, Danilo Moretti-Ferreira ORCID
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Cleft lip and/or palate (CL/P) is a major congenital defect with complex etiology, including multiple genetic and environmental factors. Approximately two thirds of the cases are not accompanied by other anomalies and are called nonsyndromic (NS). In the present study, we performed transmission distortion analysis of the MSX1-CA, TGFB3-CA and MTHFR-C677T polymorphisms in 60 parent-child triads, in which the NS-CL/ P affected child had at least one affected parent. No association with genes MSX1 or TGFB3 was found, but the results were suggestive of an association of the MTHFR-C677T polymorphism with NS-CL/P. © 2006 Sociedade Brasileira de Genética.