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Wiley-VCH Verlag, ChemInform, 3(37), 2006

DOI: 10.1002/chin.200603190

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Evaluation of Strychnos pseudoquina St. Hil. leaves extract on gastrointestinal activity in mice

Journal article published in 2005 by Marcelo Aparecido Da Silva, Marcelo Aparecido da Silva, Lc dos Santos ORCID, Lucia Regina Machado da Rocha, Marcelo Aparecido Da Silva, Bruna Paola Murino Rafacho ORCID, Clelia Akiko Hiruma-Lima ORCID, Lúcia Regina Machado Da Rocha ORCID, Lúcia Regina Machado da Rocha, Lourdes Campaner Dos Santos, Lourdes Campaner dos Santos, Miriam Sannomiya, Alba Regina Monteiro Souza-Brito, Alba Regina Monteiro Souza-Brito, Wagner Vilegas
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This paper is available in a repository.

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Abstract

Strychnos pseudoquina St. Hil. (Loganiaceae) was investigated for its ability to protect the gastric mucosa against injuries caused by non-steroidal anti-inflammatory drugs (piroxicam) and a necrotizing agent (HCl/EtOH) in mice. The MeOH extract and enriched alkaloidic fraction (EAF) provided significant protection in experimental models wheer used at doses of 250 and 1000 mg/kg. In vivo tests were carried out to evaluate for possible toxic effects and no mortality was observed up to the 5 g/kg dose level. Phytochemical investigation led to the isolation of a new indole alkaloid, which elucidated the observed pharmacological effects. © 2005 Pharmaceutical Society of Japan.