Transit timing variations provide a powerful tool for confirming and characterizing transiting planets, as well as detecting non-transiting planets. We report the results an updated TTV analysis for 1481 planet candidates (Borucki et al. 2011; Batalha et al. 2012) based on transit times measured during the first sixteen months of Kepler observations. We present 39 strong TTV candidates based on long-term trends (2.8% of suitable data sets). We present another 136 weaker TTV candidates (9.8% of suitable data sets) based on excess scatter of TTV measurements about a linear ephemeris. We anticipate that several of these planet candidates could be confirmed and perhaps characterized with more detailed TTV analyses using publicly available Kepler observations. For many others, Kepler has observed a long-term TTV trend, but an extended Kepler mission will be required to characterize the system via TTVs. We find that the occurrence rate of planet candidates that show TTVs is significantly increased (~68%) for planet candidates transiting stars with multiple transiting planet candidate when compared to planet candidates transiting stars with a single transiting planet candidate. ; Comment: Accepted to ApJ; 9 pages, incl. 3 B&W figures, 1 table, 2 electronic datasets available as ancillary files; Includes analyses of more planet candidates; Transit times and additional figures at http://www.astro.ufl.edu/~eford/data/kepler/