Published in
Elsevier, Tetrahedron Letters, 46(44), p. 8379-8382
DOI: 10.1016/j.tetlet.2003.09.128
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Synthesis of an oxyamino-containing phenanthroline derivative for the efficient preparation of phenanthroline oligonucleotide oxime conjugates
Journal article published in 2003 by
Stéphanie Deroo,
Eric Defrancq 
,
Cécile Moucheron,
Andrée Kirsch De Mesmaeker,
Andrée Kirsch-De Mesmaeker,
Pascal Dumy
,
Cécile Moucheron,
Andrée Kirsch De Mesmaeker,
Andrée Kirsch-De Mesmaeker,
Pascal Dumy
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Abstract
A phenanthroline derivative bearing an oxyamino linker was efficiently prepared from commercial 5-nitro-1,10-phenanthroline. The subsequent reaction with an oligonucleotide containing an aldehyde either at the 5′ end or the 3′ end afforded, in good yield, the phenanthroline–oligonucleotide conjugates through oxime bond formation.