Dissemin is shutting down on January 1st, 2025

Published in

American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(58), p. 6962-6965, 2014

DOI: 10.1128/aac.03486-14

Links

Tools

Export citation

Search in Google Scholar

Respiratory flexibility in response to inhibition of cytochrome c oxidase in Mycobacterium tuberculosis

Journal article published in 2014 by Kriti Arora, Bernardo Ochoa-Montaño, Patricia S. Tsang, Tom L. Blundell, Stephanie S. Dawes, Valerie Mizrahi, Tracy Bayliss, Claire J. Mackenzie, Laura A. T. Cleghorn ORCID, Peter C. Ray, Paul G. Wyatt, Eugene Uh, Jinwoo Lee, Clifton E. Barry, Helena I. Boshoff
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Green circle
Postprint: archiving allowed
Upload
Orange circle
Published version: archiving restricted
Upload
Policy details
Data provided by SHERPA/RoMEO

Abstract

ABSTRACT We report here a series of five chemically diverse scaffolds that have in vitro activities on replicating and hypoxic nonreplicating bacilli by targeting the respiratory bc 1 complex in Mycobacterium tuberculosis in a strain-dependent manner. Deletion of the cytochrome bd oxidase generated a hypersusceptible mutant in which resistance was acquired by a mutation in qcrB . These results highlight the promiscuity of the bc 1 complex and the risk of targeting energy metabolism with new drugs.