Published in

Portland Press, Biochemical Journal, 1(458), p. 185-185, 2014

DOI: 10.1042/bj4580185

Portland Press, Biochemical Journal, 2(457), p. 231-242, 2013

DOI: 10.1042/bj20131214

Links

Tools

Export citation

Search in Google Scholar

Cap-binding complex (CBC)

Journal article published in 2013 by Thomas Gonatopoulos-Pournatzis, Victoria H. Cowling ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

Full text: Download

Red circle
Preprint: archiving forbidden
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

The 7mG (7-methylguanosine cap) formed on mRNA is fundamental to eukaryotic gene expression. Protein complexes recruited to 7mG mediate key processing events throughout the lifetime of the transcript. One of the most important mediators of 7mG functions is CBC (cap-binding complex). CBC has a key role in several gene expression mechanisms, including transcription, splicing, transcript export and translation. Gene expression can be regulated by signalling pathways which influence CBC function. The aim of the present review is to discuss the mechanisms by which CBC mediates and co-ordinates multiple gene expression events.