Published in

American Chemical Society, Nano Letters, 2(11), p. 505-511

DOI: 10.1021/nl103349s

Links

Tools

Export citation

Search in Google Scholar

Nanotopographic control of neuronal polarity

Journal article published in 2011 by Aldo Ferrari, Marco Cecchini ORCID, Akshay Dhawan, Silvestro Micera, Ilaria Tonazzini ORCID, Ripalta Patty Stabile, Dario Pisignano, Fabio Beltram
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Orange circle
Postprint: archiving restricted
  • Must obtain written permission from Editor
  • Must not violate ACS ethical Guidelines
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

We employ simple geometrical rules to design a set of nanotopographies able to interfere with focal adhesion establishment during neuronal differentiation. Exploiting nanoimprint lithography techniques on cyclic-olefin-copolymer films, we demonstrate that by varying a single topographical parameter the orientation and maturation of focal adhesions can be finely modulated yielding independent control over the final number and the outgrowth direction of neurites. Taken together, this report provides a novel and promising approach to the rational design of biocompatible textured substrates for tissue engineering applications.