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American Thoracic Society, American Journal of Respiratory and Critical Care Medicine, 8(177), p. 887-895, 2008

DOI: 10.1164/rccm.200707-990oc

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Reactive oxygen species regulate neutrophil recruitment and survival in pneumococcal pneumonia

Journal article published in 2008 by Helen M. Marriott, Laura E. Jackson, Thomas S. Wilkinson, A. John Simpson, A. John Simpson, Tim J. Mitchell, David J. Buttle, Simon S. Cross, Paul G. Ince, Paul G. Hellewell, Moira K. B. Whyte, David H. Dockrell ORCID
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This paper is available in a repository.

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Abstract

During pneumococcal pneumonia, NADPH oxidase-derived reactive oxygen species are redundant for host defense but limit neutrophil recruitment and survival. Decreased NADPH oxidase-dependent reactive oxygen species production is well tolerated and improves disease outcome during pneumococcal pneumonia by removing neutrophils from the tight constraints of reactive oxygen species-mediated regulation.