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Instituto Oswaldo Cruz, Ministério da Saúde, Memórias do Instituto Oswaldo Cruz., 5(109), p. 522-524, 2014

DOI: 10.1590/0074-0276140240

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Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

Journal article published in 2014 by Val,Fernando Fonseca, Fernando Fonseca Val, Vanderson Souza Sampaio ORCID, Sampaio,Vanderson Souza, Cassera,Maria Belén, Maria Belén Cassera, Raquel Tapajós Andrade, Pedro Luiz Tauil, Andrade,Raquel Tapajós, Tauil,Pedro Luiz, Monteiro,Wuelton Marcelo, Wuelton Marcelo Monteiro, Lacerda,Marcus Vinícius Guimarães, Marcus Vinícius Guimarães Lacerda
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.