Dissemin is shutting down on January 1st, 2025

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Nature Research, Nature Genetics, 1(40), p. 23-25, 2007

DOI: 10.1038/ng.2007.48

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Psoriasis is associated with increased β-defensin genomic copy number

Journal article published in 2007 by Edward J. Hollox, Ulrike Huffmeier, Patrick L. J. M. Zeeuwen ORCID, Raquel Palla, Jesús Lascorz, Diana Rodijk-Olthuis, Peter C. M. van de Kerkhof, Heiko Traupe, Gys de Jongh, Martin den Heijer ORCID, André Reis ORCID, John A. L. Armour, Joost Schalkwijk
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Psoriasis is a common inflammatory skin disease with a strong genetic component. We analyzed the genomic copy number polymorphism of the beta-defensin region on human chromosome 8 in 179 Dutch individuals with psoriasis and 272 controls and in 319 German individuals with psoriasis and 305 controls. Comparisons in both cohorts showed a significant association between higher genomic copy number for beta-defensin genes and risk of psoriasis. ; 16448