Cosmic Microwave Background observations became the tool to probe the the first events of cosmic history. After WMAP data releases, galactic and extragalactic foregrounds are perceived as the main limiting uncertainity for the near-future search for the B-mode polarization inprints from the inflationary era, either through satellites or ground-based experiments like Brain at Dome-C. A combination of technology, scanning strategy and above all, accurate knowledge of polarized foregrounds will be necessary for an optimal mapping of B-mode CMB Polarization. In addition, the search for a better understanding of the galactic foregrounds will provide unprecedented knowledge on the Milky Way structure and star formation. © 2010 EAS, EDP Sciences.