Published in

Elsevier, Diabetes Research and Clinical Practice, 1(77), p. 134-140

DOI: 10.1016/j.diabres.2006.10.018

Links

Tools

Export citation

Search in Google Scholar

VDR polymorphisms influence the immune response in type 1 diabetic children from Santiago, Chile

Journal article published in 2007 by Diego García ORCID, Bárbara Angel Badillo ORCID, Elena Carrasco, Cecilia Albala Brevis, José Luis Santos, Francisco Pérez Bravo
This paper is available in a repository.
This paper is available in a repository.

Full text: Download

Green circle
Preprint: archiving allowed
Upload
Red circle
Postprint: archiving forbidden
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Objective: To evaluate the influence of ApaI, BsmI and TaqI polymorphisms of the VDR gene and HLA-DQB1* alleles in type 1 diabetic children and to assess their possible relationship with circulating levels of 25-hydroxyvitamin D3, auto-antibodies, and INFg/TGFb1 cytokines levels in Chilean cases and controls. Methods: DNA and serum samples from 216 newly diagnosed type 1 diabetic and 203 unrelated control children were evaluated for IA-2 and GAD65 auto-antibodies, 25-hydroxyvitamin D3 levels, HLA-DQB1* alleles, and VDR gene polymorphisms. Results: The frequency of the b allele and the bb genotype in type 1 diabetic patients was significantly lower compared with the control group (0.635 versus 0.749, p