Dissemin is shutting down on January 1st, 2025

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Wiley Open Access, Molecular Systems Biology, 1(9), p. 650, 2013

DOI: 10.1038/msb.2013.7

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Network balance via CRY signalling controls the Arabidopsis circadian clock over ambient temperatures

Journal article published in 2013 by Peter D. Gould, Nicolas Ugarte, Mirela Domija, Mirela Domijan, Maria J. (Maria João) Costa, Julia Foreman, Dana MacGregor, Ken Rose, Jayne Griffiths, Andrew J. (Andrew J.) Millar, Bärbel Finkenstädt, Steven Penfield, David A. (David A.) Rand, Karen J. Halliday, Anthony J. W. Hall ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Circadian clocks exhibit ‘temperature compensation', meaning that they show only small changes in period over a broad temperature range. Several clock genes have been implicated in the temperature-dependent control of period in Arabidopsis. We show that blue light is essential for this, suggesting that the effects of light and temperature interact or converge upon common targets in the circadian clock. Our data demonstrate that two cryptochrome photoreceptors differentially control circadian period and sustain rhythmicity across the physiological temperature range. In order to test the hypothesis that the targets of light regulation are sufficient to mediate temperature compensation, we constructed a temperature-compensated clock model by adding passive temperature effects into only the light-sensitive processes in the model. Remarkably, this model was not only capable of full temperature compensation and consistent with mRNA profiles across a temperature range, but also predicted the temperature-dependent change in the level of LATE ELONGATED HYPOCOTYL, a key clock protein. Our analysis provides a systems-level understanding of period control in the plant circadian oscillator.