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Associação Brasileira de Psiquiatria - ABP, Revista Brasileira de Psiquiatria, 3(33), p. 268-274

DOI: 10.1590/s1516-44462011000300010

Associação Brasileira de Psiquiatria - ABP, Revista Brasileira de Psiquiatria, 3(33), p. 268-274

DOI: 10.1590/s1516-44462011005000009

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Serum levels of IL-6, IL-10 and TNF-α in patients with bipolar disorder and schizophrenia: differences in pro- and anti-inflammatory balance

Journal article published in 2011 by Belmonte de-Abreu,Paulo Silva, Mauricio Kunz, Kunz,Mauricio, Ceresér,Keila Maria, Keila Maria Ceresér, Fries,Gabriel Rodrigo, Pedro Domingues Goi ORCID, Teixeira,Antonio L., Gabriel Rodrigo Fries ORCID, Fernandes,Brisa Simões, Antonio L. Teixeira, Kauer-Sant'Anna,Márcia, Brisa Simões Fernandes, Kapczinski,Flavio, Paulo Silva Belmonte-De-Abreu and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

OBJECTIVE: Previous reports suggest that cytokines act as potential mediators of the interaction between the immune and neuroendocrine systems, and that a proinflammatory state may be associated with bipolar disorder and schizophrenia. The aim is to compare cytokine levels in both disorders. METHOD: Twenty euthymic bipolar disorder patients, 53 chronic stabilized schizophrenia patients and 80 healthy controls were recruited. Subjects were all non-smokers and non-obese. Cytokines TNF-α, IL-6, and IL-10 were examined by sandwich ELISA. RESULTS: IL-6 levels were increased in schizophrenia patients when compared to controls (p