This study describes the epidemiology of laboratory- confirmed pandemic influenza H1N1 within north Queensland, Australia. We collected data on all specimens tested for influenza (including H1N1) by polymerase chain reaction between May and August 2009 at Townsville Hospital. Patients requiring admission to hospital and a proportion of non-admitted patients had clinical characteristics recorded. Multi-variable logistic regression analysis was used to identify independent predictors for admission. Patients requiring admission were on average older, less likely to be of Aboriginal or Torres Strait Islander descent and more likely to be pregnant, female or suffer from diabetes mellitus. Oseltamivir provision was significantly higher within the Aboriginal or Torres Strait Islander patient population. However, when the relative sizes of the local Indigenous and non- Indigenous populations were considered, the relative risk of hospital admission for Indigenous people was found to be 7.9 (4.7–13.2) in comparison to non-Indigenous.