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Sociedade Brasileira de Medicina Tropical - SBMT, Revista da Sociedade Brasileira de Medicina Tropical, 4(46), p. 506-509, 2013

DOI: 10.1590/0037-8682-1451-2013

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Phenotypic detection of metallo-β-lactamases in Pseudomonas aeruginosa and Acinetobacter baumannii isolated from hospitalized patients in São Luis, State of Maranhão, Brazil

Journal article published in 2013 by Carvalho,Roberto Morais Luz De, Roberto Morais Luz de Carvalho, Roberto Morais Luz de Carvalho, Sirlei Garcia Marques, Marques,Sirlei Garcia, Goncalves,Luis Henrique Bastos, Luis Henrique Bastos Goncalves, Afonso Gomes Abreu ORCID, Silvio Gomes Monteiro, Abreu,Afonso Gomes, Monteiro,Silvio Gomes, Azizedite Guedes Goncalves, Goncalves,Azizedite Guedes
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Introduction Acquired metallo-β-lactamases (MβL) are emerging determinants of resistance in Pseudomonas aeruginosa and Acinetobacter baumannii. The objectives of this study were to phenotypically detect MβL in imipenem-resistant P. aeruginosa and A. baumannii, to investigate the association between MβL-positive strains and hospitals, and to compare the resistance profiles of MβL-producing and non-MβL-producing strains. Methods The approximation disk and combined disk assay methods were used in this study. Results A total of 18 (38.3%) P. aeruginosa isolates and 1 (5.6%) A. baumannii isolate tested positive for the presence of MβL. Conclusions These results demonstrate the need for strict surveillance and for the adoption of preventive measures to reduce the spread of infection and potential outbreaks of disease caused by MβL-producing microorganisms.