Two-Photon Excitation of Porphyrin-Functionalized Porous Silicon Nanoparticles for Photodynamic Therapy
Journal article published in 2014 by
Emilie Secret,
Hugues Vincent,
Marie Maynadier,
Audrey Gallud 
,
Arnaud Chaix,
Elise Bouffard,
Magali Gary-Bobo,
Nathalie Marcotte,
Olivier Mongin,
Khaled El Cheikh,
Khaled El Cheikh,
Melanie Auffan,
Céline Frochot,
Alain Morère,
Philippe Maillard
and other authors.
,
Arnaud Chaix,
Elise Bouffard,
Magali Gary-Bobo,
Nathalie Marcotte,
Olivier Mongin,
Khaled El Cheikh,
Khaled El Cheikh,
Melanie Auffan,
Céline Frochot,
Alain Morère,
Philippe Maillard
and other authors.
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Abstract
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of a pendant porphyrin using NIR laser light, for imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through a mannose receptor-mediated endocytosis mechanism to provide a 3-fold enhancement of the 2-photon PDT effect.