PurposeThe subject of occupational safety and health (OSH) is increasingly gaining the interest of policy makers and researchers in European countries given that the economic and social losses from work‐related injuries and diseases are quite substantial. Under this light, this paper aims to present an overview of the Greek legislation framework regarding OSH issues, and the current status of empirical research on the subject in Greece. In addition, the paper seeks to identify the knowledge gaps and methodological shortcomings of the existing literature in order to contribute towards future research in the OSH field in Greece.Design/methodology/approachThe authors conducted an extensive literature review of numerous publications, reports and institutions' databases.FindingsThe results suggest that empirical up to date research in Greece is rather inadequate, mainly because of the absence of econometric methods to validate the findings. The available Greek databases indicate that while the number of working accidents has decreased over time, the severity seems to be increasing. Males are more prone to accidents, diseases and negative working conditions. Work‐related stress is an aspect of occupational problems that has been the subject of many Greek studies.Research limitations/implicationsAlthough the legal framework is quite adequate, there is a need for both prevention strategies and enforcement of the existing safety regulations. Furthermore, a substantial research gap is observed in Greece. Therefore, more systematic research is needed on the determinants of injuries and on their effects on job participation and productivity.Originality/valueThe paper presents a detailed review of the current state of research regarding OSH issues in Greece.