A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Muther, Consortium; Scott, Robert A.; Wouter Jukema, J.; Tönjes, Anke; Manning, Alisa K.; Tm, Frayling; Hivert, Marie-France; Tb, Harris; Wh, Kao; Sl, Kardia; Grimsby, Jonna L.; Yv, Sun; Bouatia-Naji, Nabila; Toenjes, Anke; Chen, Han; Sh, Wild; Liu, Ching-Ti; Bielak, Lawrence F.; Rybin, Denis; Sm, Willems; Hottenga, Jouke-Jan; Prokopenko, Inga; Jackson, Anne U.; van Duijn, Cornelia M.; Amin, Najaf; Van Duijn, Cm M.; de Andrade, Mariza; Barnes, Daniel; Lahti, Jari; Johnson, Toby; Lecoeur, Cecile; Cadby, Gemma; Ingelsson, Erik; Martínez-Larrad, María Teresa; Salo, Perttu; Sattar, Naveed; Kanoni, Stavroula; Montasser, May E.; Shungin, Dmitry; Navarro, Pau; Strawbridge, Rona J.; Perry, John R. B.; Ladenvall, Claes; Rasmussen-Torvik, Laura J.; Tanaka, Toshiko; Lagou, Vasiliki; An, Ping; de Faire, Ulf; Andrews, Jeanette S.; Liu, Ym; Aspelund, Thor; Ak, Manning; Atalay, Mustafa; Aulchenko, Yurii; Diagram, Consortium; Balkau, Beverley; Bandinelli, Stefania; Beckmann, Jacques S.; Beilby, John P.; Mt, Martinez Larrad; de Geus, Eco; Bellis, Claire; Bergman, Richard N.; Mf, Hivert; Blangero, John; Boban, Mladen; Me, Montasser; Boehnke, Michael; Boerwinkle, Eric; De Andrade, M.; Bonnycastle, Lori Ll; Jr, Perry; Boomsma, Dorret I.; Lj, Rasmussen Torvik; Borecki, Ingrid B.; Böttcher, Yvonne; Bouchard, Claude; Liu, Yongmei; Brunner, Eric; Budimir, Danijela; Rj, Strawbridge; Campbell, Harry; Carlson, Olga; Cm, van Duijn; Chines, Peter S.; Js, Andrews; Clarke, Robert; Collins, Francis S.; Corbatón-Anchuelo, Arturo; Ra, Scott; Couper, David; Jl, Grimsby; Dedoussis, George V.; Deloukas, Panos; Js, Beckmann; Dimitriou, Maria; Egan, Josephine M.; Eiriksdottir, Gudny; Jp, Beilby; Erdos, Michael R.; Eriksson, Johan G.; Rn, Bergman; Eury, Elodie; Ferrucci, Luigi; Ford, Ian; Forouhi, Nita G.; Ll, Bonnycastle; Fox, Caroline S.; Franzosi, Maria Grazia; Di, Boomsma; Franks, Paul W.; Frayling, Timothy M.; Ib, Borecki; Froguel, Philippe; Galan, Pilar; De Faire, U.; Gigante, Bruna; Boettcher, Yvonne; Glazer, Nicole L.; Goel, Anuj; Groop, Leif; Ps, Chines; Gudnason, Vilmundur; Hallmans, Göran; Hamsten, Anders; Hansson, Ola; Fs, Collins; Harris, Tamara B.; Hayward, Caroline; Jj, Hottenga; Heath, Simon; Hercberg, Serge; Gv, Dedoussis; Hicks, Andrew Aa; Hingorani, Aroon; Hofman, Albert; Hui, Jennie; Hung, Joseph; Jm, Egan; Jarvelin, Marjo-Riitta; De Geus, E.; Jhun, Min A.; Mr, Erdos; Johnson, Paul C. D.; Jukema, Jw Wouter; Jula, Antti; Au, Jackson; Kao, Wh H.; Kaprio, Jaakko; Kardia, Sharon L. R.; Keinanen-Kiukaanniemi, Sirkka; Kivimaki, Mika; Ng, Forouhi; Kolcic, Ivana; Kovacs, Peter; Kumari, Meena; Kuusisto, Johanna; Kyvik, Kirsten Ohm; Cs, Fox; Laakso, Markku; Lakka, Timo; Lannfelt, Lars; Launer, Lenore J.; Mg, Franzosi; Leander, Karin; Li, Guo; Lind, Lars; Lindström, Jaana; Räikkönen, Katri; Lobbens, Stéphane; Pw, Franks; Loos, Ruth J. F.; Luan, Jian’an; Lyssenko, Valeriya; Jg, Eriksson; Lathrop, Gm Mark; Mägi, Reedik; Saaristo, Timo; Magnusson, Patrik K. E.; Sabater-Lleal, Maria; Marmot, Michael; Ct, Liu; Meneton, Pierre; Salomaa, Veikko; Savage, David B.; Mohlke, Karen L.; Saxena, Richa; Mooser, Vincent; Nl, Glazer; Schwarz, Peter; Morken, Mario A.; Miljkovic, Iva; Seedorf, Udo; Narisu, Narisu; Sennblad, Bengt; Shuldiner, Alan R.; Lf, Bielak; O'Connell, Jeff; Sijbrands, Eric J. G.; Serrano-Ríos, Manuel; Ong, Ken Kk; Oostra, Ben A.; Siscovick, David S.; Palmer, Lyle J.; Smit, Johannes H.; Palotie, Aarno; Small, Kerrin S.; Pankow, James S.; Smith, Nicholas L.; Aa, Hicks; Mark Lathrop, G.; Smith, Albert Vernon; Peden, John F.; Pehlic, Marina; Stančáková, Alena; Peltonen, Leena; Pedersen, Nancy L.; Mr, Jarvelin; Stirrups, Kathleen; Penninx, Brenda W. J. H.; Sun, Yan V.; Stumvoll, Michael; Ma, Jhun; Pericic, Marijana; Swift, Amy J.; Perola, Markus; Perusse, Louis; Tönjes, Anke; Pc, Johnson; Tuomilehto, Jaakko; Polasek, Ozren; Peyser, Patricia A.; Trompet, Stella; Jw, Jukema; Pramstaller, Peter Pp; Uitterlinden, Andre G.; Uusitupa, Matti; Province, Michael A.; Rauramaa, Rainer; Rehnberg, Emil; Vikström, Max; Ko, Kyvik; Rice, Ken; Vohl, Marie-Claude; Vitart, Veronique; Rotter, Jerome I.; Voight, Benjamin F.; Rudan, Igor; Gm, Lathrop; Ruokonen, Aimo; Vollenweider, Peter; Lj, Launer; Waeber, Gerard; Waterworth, Dawn M.; Watkins, Hugh; Wheeler, Eleanor; Rj, Loos; Widen, Elisabeth; Pk, Magnusson; Wild, Sarah H.; Willems, Sara M.; Kl, Mohlke; Willemsen, Gonneke; Magi, Reedik; Wilson, James F.; Ma, Morken; Witteman, Jacqueline C. M.; Kk, Ong; Ba, Oostra; Lj, Palmer; Wright, Alan F.; Js, Pankow; Jf, Peden; Nl, Pedersen; Yaghootkar, Hanieh; Pa, Peyser; Pp, Pramstaller; Zelenika, Diana; Ma, Province; Zemunik, Tatijana; Ji, Rotter; Raikkonen, Katri; Db, Savage; Zgaga, Lina; Ar, Shuldiner; Ej, Sijbrands; Ds, Siscovick; Wareham, Nicholas J.; Böttcher, Yvonne; Jh, Smit; Ks, Small; Nl, Smith; Watanabe, Richard M.; Av, Smith; Aj, Swift; Ag, Uitterlinden; Mc, Vohl; Bf, Voight; Dm, Waterworth; Jf, Wilson; Jc, Witteman; Af, Wright; Mr, Järvelin; Geus, E. J. C.; Mägi, Reedik; Consortium, DIAbetes Genetics Replication And Meta-Analysis (Diagram); O’Connell, Jeff; Consortium, Multiple Tissue Human Expression Resource (MUTHER); Nj, Wareham; Pérusse, Louis; Mi, McCarthy; McCarthy, Mark I.; Barroso, Inês; Rm, Watanabe; Florez, Jose C.; Jc, Florez; Dupuis, Josee; Meigs, James B.; Jb, Meigs; Langenberg, Claudia; ,

Dissemin
Inga Prokopenko
Muther et al., 2012

Tools

Export citation

Format

@article{Muther2012,
  abstract = {Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P &lt; 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.},
  author = {Muther, Consortium and Scott, Robert A. and Wouter Jukema, J. and Tönjes, Anke and Manning, Alisa K. and Tm, Frayling and Hivert, Marie-France and Tb, Harris and Wh, Kao and Sl, Kardia and Grimsby, Jonna L. and Yv, Sun and Bouatia-Naji, Nabila and Toenjes, Anke and Chen, Han and Sh, Wild and Liu, Ching-Ti and Bielak, Lawrence F. and Rybin, Denis and Sm, Willems and Hottenga, Jouke-Jan and Prokopenko, Inga and Jackson, Anne U. and van Duijn, Cornelia M. and Amin, Najaf and Van Duijn, Cm M. and de Andrade, Mariza and Barnes, Daniel and Lahti, Jari and Johnson, Toby and Lecoeur, Cecile and Cadby, Gemma and Ingelsson, Erik and Martínez-Larrad, María Teresa and Salo, Perttu and Sattar, Naveed and Kanoni, Stavroula and Montasser, May E. and Shungin, Dmitry and Navarro, Pau and Strawbridge, Rona J. and Perry, John R. B. and Ladenvall, Claes and Rasmussen-Torvik, Laura J. and Tanaka, Toshiko and Lagou, Vasiliki and An, Ping and de Faire, Ulf and Andrews, Jeanette S. and Liu, Ym and Aspelund, Thor and Ak, Manning and Atalay, Mustafa and Aulchenko, Yurii and Diagram, Consortium and Balkau, Beverley and Bandinelli, Stefania and Beckmann, Jacques S. and Beilby, John P. and Mt, Martinez Larrad and de Geus, Eco and Bellis, Claire and Bergman, Richard N. and Mf, Hivert and Blangero, John and Boban, Mladen and Me, Montasser and Boehnke, Michael and Boerwinkle, Eric and De Andrade, M. and Bonnycastle, Lori Ll and Jr, Perry and Boomsma, Dorret I. and Lj, Rasmussen Torvik and Borecki, Ingrid B. and Böttcher, Yvonne and Bouchard, Claude and Liu, Yongmei and Brunner, Eric and Budimir, Danijela and Rj, Strawbridge and Campbell, Harry and Carlson, Olga and Cm, van Duijn and Chines, Peter S. and Js, Andrews and Clarke, Robert and Collins, Francis S. and Corbatón-Anchuelo, Arturo and Ra, Scott and Couper, David and Jl, Grimsby and Dedoussis, George V. and Deloukas, Panos and Js, Beckmann and Dimitriou, Maria and Egan, Josephine M. and Eiriksdottir, Gudny and Jp, Beilby and Erdos, Michael R. and Eriksson, Johan G. and Rn, Bergman and Eury, Elodie and Ferrucci, Luigi and Ford, Ian and Forouhi, Nita G. and Ll, Bonnycastle and Fox, Caroline S. and Franzosi, Maria Grazia and Di, Boomsma and Franks, Paul W. and Frayling, Timothy M. and Ib, Borecki and Froguel, Philippe and Galan, Pilar and De Faire, U. and Gigante, Bruna and Boettcher, Yvonne and Glazer, Nicole L. and Goel, Anuj and Groop, Leif and Ps, Chines and Gudnason, Vilmundur and Hallmans, Göran and Hamsten, Anders and Hansson, Ola and Fs, Collins and Harris, Tamara B. and Hayward, Caroline and Jj, Hottenga and Heath, Simon and Hercberg, Serge and Gv, Dedoussis and Hicks, Andrew Aa and Hingorani, Aroon and Hofman, Albert and Hui, Jennie and Hung, Joseph and Jm, Egan and Jarvelin, Marjo-Riitta and De Geus, E. and Jhun, Min A. and Mr, Erdos and Johnson, Paul C. D. and Jukema, Jw Wouter and Jula, Antti and Au, Jackson and Kao, Wh H. and Kaprio, Jaakko and Kardia, Sharon L. R. and Keinanen-Kiukaanniemi, Sirkka and Kivimaki, Mika and Ng, Forouhi and Kolcic, Ivana and Kovacs, Peter and Kumari, Meena and Kuusisto, Johanna and Kyvik, Kirsten Ohm and Cs, Fox and Laakso, Markku and Lakka, Timo and Lannfelt, Lars and Launer, Lenore J. and Mg, Franzosi and Leander, Karin and Li, Guo and Lind, Lars and Lindström, Jaana and Räikkönen, Katri and Lobbens, Stéphane and Pw, Franks and Loos, Ruth J. F. and Luan, Jian’an and Lyssenko, Valeriya and Jg, Eriksson and Lathrop, Gm Mark and Mägi, Reedik and Saaristo, Timo and Magnusson, Patrik K. E. and Sabater-Lleal, Maria and Marmot, Michael and Ct, Liu and Meneton, Pierre and Salomaa, Veikko and Savage, David B. and Mohlke, Karen L. and Saxena, Richa and Mooser, Vincent and Nl, Glazer and Schwarz, Peter and Morken, Mario A. and Miljkovic, Iva and Seedorf, Udo and Narisu, Narisu and Sennblad, Bengt and Shuldiner, Alan R. and Lf, Bielak and O'Connell, Jeff and Sijbrands, Eric J. G. and Serrano-Ríos, Manuel and Ong, Ken Kk and Oostra, Ben A. and Siscovick, David S. and Palmer, Lyle J. and Smit, Johannes H. and Palotie, Aarno and Small, Kerrin S. and Pankow, James S. and Smith, Nicholas L. and Aa, Hicks and Mark Lathrop, G. and Smith, Albert Vernon and Peden, John F. and Pehlic, Marina and Stančáková, Alena and Peltonen, Leena and Pedersen, Nancy L. and Mr, Jarvelin and Stirrups, Kathleen and Penninx, Brenda W. J. H. and Sun, Yan V. and Stumvoll, Michael and Ma, Jhun and Pericic, Marijana and Swift, Amy J. and Perola, Markus and Perusse, Louis and Tönjes, Anke and Pc, Johnson and Tuomilehto, Jaakko and Polasek, Ozren and Peyser, Patricia A. and Trompet, Stella and Jw, Jukema and Pramstaller, Peter Pp and Uitterlinden, Andre G. and Uusitupa, Matti and Province, Michael A. and Rauramaa, Rainer and Rehnberg, Emil and Vikström, Max and Ko, Kyvik and Rice, Ken and Vohl, Marie-Claude and Vitart, Veronique and Rotter, Jerome I. and Voight, Benjamin F. and Rudan, Igor and Gm, Lathrop and Ruokonen, Aimo and Vollenweider, Peter and Lj, Launer and Waeber, Gerard and Waterworth, Dawn M. and Watkins, Hugh and Wheeler, Eleanor and Rj, Loos and Widen, Elisabeth and Pk, Magnusson and Wild, Sarah H. and Willems, Sara M. and Kl, Mohlke and Willemsen, Gonneke and Magi, Reedik and Wilson, James F. and Ma, Morken and Witteman, Jacqueline C. M. and Kk, Ong and Ba, Oostra and Lj, Palmer and Wright, Alan F. and Js, Pankow and Jf, Peden and Nl, Pedersen and Yaghootkar, Hanieh and Pa, Peyser and Pp, Pramstaller and Zelenika, Diana and Ma, Province and Zemunik, Tatijana and Ji, Rotter and Raikkonen, Katri and Db, Savage and Zgaga, Lina and Ar, Shuldiner and Ej, Sijbrands and Ds, Siscovick and Wareham, Nicholas J. and Böttcher, Yvonne and Jh, Smit and Ks, Small and Nl, Smith and Watanabe, Richard M. and Av, Smith and Aj, Swift and Ag, Uitterlinden and Mc, Vohl and Bf, Voight and Dm, Waterworth and Jf, Wilson and Jc, Witteman and Af, Wright and Mr, Järvelin and Geus, E. J. C. and Mägi, Reedik and Consortium, DIAbetes Genetics Replication And Meta-Analysis (Diagram) and O’Connell, Jeff and Consortium, Multiple Tissue Human Expression Resource (MUTHER) and Nj, Wareham and Pérusse, Louis and Mi, McCarthy and McCarthy, Mark I. and Barroso, Inês and Rm, Watanabe and Florez, Jose C. and Jc, Florez and Dupuis, Josee and Meigs, James B. and Jb, Meigs and Langenberg, Claudia and , },
  doi = {10.1038/ng.2274},
  month = {jan},
  title = {A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance},
  url = {http://www.nature.com/articles/ng.2274.pdf},
  year = {2012}
}

Download

Export citation

Search in Google Scholar

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Journal article published in 2012 by Consortium Muther, Robert A. Scott, J. Wouter Jukema, Anke Tönjes, Alisa K. Manning, Frayling Tm, Marie-France Hivert, Harris Tb, Kao Wh, Kardia Sl, Jonna L. Grimsby, Sun Yv, Nabila Bouatia-Naji, Anke Toenjes, Han Chen and other authors. Consortium Muther, Robert A. Scott, J. Wouter Jukema, Anke Tönjes, Alisa K. Manning, Frayling Tm, Marie-France Hivert, Harris Tb, Kao Wh, Kardia Sl, Jonna L. Grimsby, Sun Yv, Nabila Bouatia-Naji, Anke Toenjes, Han Chen, Wild Sh, Ching-Ti Liu, Lawrence F. Bielak, Denis Rybin, Willems Sm, Jouke-Jan Hottenga, Inga Prokopenko

, Anne U. Jackson, Cornelia M. van Duijn, Najaf Amin, Cm M. Van Duijn, Mariza de Andrade, Daniel Barnes, Jari Lahti

, Toby Johnson

, Cecile Lecoeur, Gemma Cadby, Erik Ingelsson, María Teresa Martínez-Larrad, Perttu Salo, Naveed Sattar, Stavroula Kanoni

, May E. Montasser, Dmitry Shungin, Pau Navarro

, Rona J. Strawbridge

, John R. B. Perry, Claes Ladenvall, Laura J. Rasmussen-Torvik

, Toshiko Tanaka, Vasiliki Lagou, Ping An, Ulf de Faire, Jeanette S. Andrews, Ym Liu, Thor Aspelund, Manning Ak, Mustafa Atalay, Yurii Aulchenko, Consortium Diagram, Beverley Balkau, Stefania Bandinelli, Jacques S. Beckmann, John P. Beilby, Martinez Larrad Mt, Eco de Geus, Claire Bellis, Richard N. Bergman, Hivert Mf, John Blangero, Mladen Boban, Montasser Me, Michael Boehnke, Eric Boerwinkle, M. De Andrade, Lori Ll Bonnycastle, Perry Jr, Dorret I. Boomsma, Rasmussen Torvik Lj, Ingrid B. Borecki, Yvonne Böttcher, Claude Bouchard, Yongmei Liu, Eric Brunner, Danijela Budimir, Strawbridge Rj, Harry Campbell, Olga Carlson, van Duijn Cm, Peter S. Chines, Andrews Js, Robert Clarke, Francis S. Collins, Arturo Corbatón-Anchuelo, Scott Ra, David Couper, Grimsby Jl, George V. Dedoussis, Panos Deloukas

, Beckmann Js, Maria Dimitriou, Josephine M. Egan, Gudny Eiriksdottir, Beilby Jp, Michael R. Erdos, Johan G. Eriksson, Bergman Rn, Elodie Eury, Luigi Ferrucci, Ian Ford, Nita G. Forouhi, Bonnycastle Ll, Caroline S. Fox, Maria Grazia Franzosi, Boomsma Di, Paul W. Franks, Timothy M. Frayling, Borecki Ib, Philippe Froguel, Pilar Galan, U. De Faire, Bruna Gigante, Yvonne Boettcher, Nicole L. Glazer, Anuj Goel, Leif Groop, Chines Ps, Vilmundur Gudnason, Göran Hallmans, Anders Hamsten, Ola Hansson

, Collins Fs, Tamara B. Harris, Caroline Hayward, Hottenga Jj, Simon Heath, Serge Hercberg, Dedoussis Gv, Andrew Aa Hicks, Aroon Hingorani, Albert Hofman, Jennie Hui, Joseph Hung, Egan Jm, Marjo-Riitta Jarvelin, E. De Geus, Min A. Jhun, Erdos Mr, Paul C. D. Johnson, Jw Wouter Jukema, Antti Jula, Jackson Au, Wh H. Kao, Jaakko Kaprio, Sharon L. R. Kardia, Sirkka Keinanen-Kiukaanniemi, Mika Kivimaki

, Forouhi Ng, Ivana Kolcic, Peter Kovacs, Meena Kumari, Johanna Kuusisto, Kirsten Ohm Kyvik, Fox Cs, Markku Laakso, Timo Lakka, Lars Lannfelt, Lenore J. Launer, Franzosi Mg, Karin Leander

, Guo Li, Lars Lind, Jaana Lindström

, Katri Räikkönen, Stéphane Lobbens, Franks Pw, Ruth J. F. Loos, Jian’an Luan, Valeriya Lyssenko, Eriksson Jg, Gm Mark Lathrop, Reedik Mägi, Timo Saaristo, Patrik K. E. Magnusson, Maria Sabater-Lleal, Michael Marmot, Liu Ct, Pierre Meneton, Veikko Salomaa, David B. Savage, Karen L. Mohlke, Richa Saxena, Vincent Mooser, Glazer Nl, Peter Schwarz, Mario A. Morken, Iva Miljkovic

, Udo Seedorf

, Narisu Narisu, Bengt Sennblad, Alan R. Shuldiner, Bielak Lf, Jeff O'Connell, Eric J. G. Sijbrands, Manuel Serrano-Ríos, Ken Kk Ong, Ben A. Oostra, David S. Siscovick, Lyle J. Palmer, Johannes H. Smit, Aarno Palotie, Kerrin S. Small, James S. Pankow, Nicholas L. Smith, Hicks Aa, G. Mark Lathrop, Albert Vernon Smith

, John F. Peden, Marina Pehlic, Alena Stančáková, Leena Peltonen, Nancy L. Pedersen, Jarvelin Mr, Kathleen Stirrups, Brenda W. J. H. Penninx, Yan V. Sun, Michael Stumvoll, Jhun Ma, Marijana Pericic, Amy J. Swift, Markus Perola, Louis Perusse, Anke Tönjes, Johnson Pc, Jaakko Tuomilehto, Ozren Polasek, Patricia A. Peyser, Stella Trompet, Jukema Jw, Peter Pp Pramstaller

, Andre G. Uitterlinden, Matti Uusitupa, Michael A. Province, Rainer Rauramaa, Emil Rehnberg, Max Vikström, Kyvik Ko, Ken Rice, Marie-Claude Vohl, Veronique Vitart, Jerome I. Rotter, Benjamin F. Voight, Igor Rudan, Lathrop Gm, Aimo Ruokonen, Peter Vollenweider, Launer Lj, Gerard Waeber, Dawn M. Waterworth, Hugh Watkins, Eleanor Wheeler, Loos Rj, Elisabeth Widen, Magnusson Pk, Sarah H. Wild, Sara M. Willems, Mohlke Kl, Gonneke Willemsen, Reedik Magi, James F. Wilson, Morken Ma, Jacqueline C. M. Witteman, Ong Kk, Oostra Ba, Palmer Lj, Alan F. Wright, Pankow Js, Peden Jf, Pedersen Nl, Hanieh Yaghootkar, Peyser Pa, Pramstaller Pp, Diana Zelenika, Province Ma, Tatijana Zemunik, Rotter Ji, Katri Raikkonen, Savage Db, Lina Zgaga, Shuldiner Ar, Sijbrands Ej, Siscovick Ds, Nicholas J. Wareham, Yvonne Böttcher, Smit Jh, Small Ks, Smith Nl, Richard M. Watanabe, Smith Av, Swift Aj, Uitterlinden Ag, Vohl Mc, Voight Bf, Waterworth Dm, Wilson Jf, Witteman Jc, Wright Af, Järvelin Mr, E. J. C. Geus, Reedik Mägi, DIAbetes Genetics Replication And Meta-Analysis (Diagram) Consortium, Jeff O’Connell, Multiple Tissue Human Expression Resource (MUTHER) Consortium, Wareham Nj, Louis Pérusse, McCarthy Mi, Mark I. McCarthy, Inês Barroso, Watanabe Rm, Jose C. Florez, Florez Jc, Josee Dupuis, James B. Meigs, Meigs Jb, Claudia Langenberg,

Show less

This paper is available in a repository.

Full text: Download

Preprint: policy unknown

Upload

Postprint: policy unknown

Upload

Published version: policy unknown

Upload

Abstract

Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and β-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interactions between BMI and genetic variants. We applied a joint meta-analysis approach to test associations with fasting insulin and glucose on a genome-wide scale. We present six previously unknown loci associated with fasting insulin at P < 5 × 10(-8) in combined discovery and follow-up analyses of 52 studies comprising up to 96,496 non-diabetic individuals. Risk variants were associated with higher triglyceride and lower high-density lipoprotein (HDL) cholesterol levels, suggesting a role for these loci in insulin resistance pathways. The discovery of these loci will aid further characterization of the role of insulin resistance in T2D pathophysiology.

Links

Tools

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Abstract