The influence of process route on the microstructure and tensile behaviour of specimens prepared from hot isostatically pressed powders and extruded ingot of the burn resistant alloy, Ti25V-15Cr-2Al-0.2C (wt-%), has been investigated. Samples based on gas atomised (GA) and plasma rotating electrode process (PREP) powders have been studied. Microstructural examination shows that many PREP powder particles are single crystals, whereas GA particles are polycrystalline. The mechanical properties of hot isostatically pressed specimens have been assessed using tensile testing monitored by acoustic emission, while microstructures have been characterised by synchrotron X-ray microtomography and optical and analytical scanning electron microscopy. Tomographic examination revealed a small fraction (