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EMBO Press, The EMBO Journal, 21(31), p. 4140-4152, 2012

DOI: 10.1038/emboj.2012.242

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End-binding protein 1 controls signal propagation from the T cell receptor

Journal article published in 2012 by Noa Beatriz Martín-Cófreces, Martín Cófreces Nb, Francesc Baixauli, María José López, López Mj, Diana Gil, Alicia Monjas, Balbino Alarcón, Francisco Sánchez-Madrid ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

The role of microtubules (MTs) in the control and dynamics of the immune synapse (IS) remains unresolved. Here, we show that T cell activation requires the growth of MTs mediated by the plus-end specific protein end-binding 1 (EB1). A direct interaction of the T cell receptor (TCR) complex with EB1 provides the molecular basis for EB1 activity promoting TCR encounter with signalling vesicles at the IS. EB1 knockdown alters TCR dynamics at the IS and prevents propagation of the TCR activation signal to LAT, thus inhibiting activation of PLCγ1 and its localization to the IS. These results identify a role for EB1 interaction with the TCR in controlling TCR sorting and its connection with the LAT/PLCγ1 signalosome.