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Public Library of Science, PLoS ONE, 11(7), p. e49072, 2012

DOI: 10.1371/journal.pone.0049072

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Diffusion Tensor Metrics as Biomarkers in Alzheimer's Disease

Journal article published in 2012 by Julio Acosta-Cabronero, Stephanie Alley, Guy B. Williams ORCID, George Pengas, Peter J. Nestor
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Although diffusion tensor imaging has been a major research focus for Alzheimer’s disease in recent years, it remains unclear whether it has sufficient stability to have biomarker potential. To date, frequently inconsistent results have been reported, though lack of standardisation in acquisition and analysis make such discrepancies difficult to interpret. There is also, at present, little knowledge of how the biometric properties of diffusion tensor imaging might evolve in the course of Alzheimer’s disease.