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Georg Thieme Verlag, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 07(2010), p. 1142-1142

DOI: 10.1055/s-0029-1219805

Georg Thieme Verlag, Synlett: Accounts and Rapid Communications in Synthetic Organic Chemistry, 04(2010), p. 521-524

DOI: 10.1055/s-0029-1218543

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Design and Synthesis of an Activity-Based Probe Template for Protein Kinases

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

A potential activity-based probe for protein kinases was designed around mechanism-based inhibitors of insulin receptor ­kinase. The probe was synthesized by a chemoselective conjugate addition of ATPγS to an epoxyenone.