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Oxford University Press, Human Molecular Genetics, 19(19), p. 3885-3894, 2010

DOI: 10.1093/hmg/ddq303

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Genome-wide association analysis identifies multiple loci related to resting heart rate

Journal article published in 2010 by Mark Eijgelsheim, Christopher Newton-cheh, Paul I. W. de Bakker, P. I. W. Bakker, Nona Sotoodehnia, Martina Müller, C. J. O. Donnell, Alanna C. Morrison, Albert V. Smith ORCID, Aaron Isaacs, Serena Sanna ORCID, Marcus Dörr, Pau Navarro, Christian Fuchsberger, Ilja M. Nolte and other authors.
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This paper is available in a repository.

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Abstract

Higher resting heart rate is associated with increased cardiovascular disease and mortality risk. Though heritable factors play a substantial role in population variation, little is known about specific genetic determinants. This knowledge can impact clinical care by identifying novel factors that influence pathologic heart rate states, modulate heart rate through cardiac structure and function or by improving our understanding of the physiology of heart rate regulation. To identify common genetic variants associated with heart rate, we performed a meta-analysis of 15 genome-wide association studies (GWAS), including 38,991 subjects of European ancestry, estimating the association between age-, sex- and body mass-adjusted RR interval (inverse heart rate) and approximately 2.5 million markers. Results with P