OBJECTIVE: The study aims to evaluate maxillary molars’ root and root canal morphology among the Saudi population using Cone-Beam Computed Tomography scanning (CBCT). SUBJECTS AND METHODS: Retrospectively, the CBCT scans of 483 Saudi nationals were evaluated to identify the number of roots and root canals in maxillary first and second molars. The records were tabulated and classified according to Vertucci and a new system for root and canal classification given by Ahmed and Dummer. Fisher’s exact test was used to analyze the data statistically. To check for symmetry, comparisons were made between all the maxillary first molars (MFM’s) and maxillary second molars (MSM’s) on opposing quadrants. Inter Observer variability was seen using Cohen’s Kappa test. RESULTS: MFM’s presented with three roots with Type II Vertucci canal configuration (VC) commonly seen among them. MSM’s had more variations in the number of roots and canals, although three roots and Type I VC were predominantly seen. When comparing the two genders statistically significant difference was observed in both maxillary molars at a 5% level using Fisher’s exact test. Three roots with four canals (3R4C) were predominantly observed in the MFM’s (85.6%) and three roots with three canals (3R3C) identified in 51.95% were more common than 3R4C (43.55%) in MSM’s. Both the maxillary molars bilaterally, exhibited a high percentage of symmetry in root and canal configurations. CONCLUSIONS: Identification of root canal morphology of molars would reduce the chances of root canal failures by making sure all canals are obturated. This study provides supplemental information about the root canals of maxillary molars in a Saudi Arabian subpopulation.