This study aimed to investigate the dietary effects of mycotoxin adsorbents Mycostop Premium® and Mycostop Duplo® on piglets' productive performance and serum enzyme activities. A total of 100 weaned piglets (28 days old) were randomly assigned to five dietary treatment groups (20 piglets in each group) for a duration of 42 days. The dietary treatments included: control group C with no mycotoxin adsorbent; group E1 supplemented with Mycostop Premium® adsorbent in amount of 1kg/t of feed; group E2 supplemented with Mycostop Premium® adsorbent in amount of 2.5kg/t of feed; group E3 supplemented with Mycostop Duplo® adsorbent in amount of 1kg/t of feed; and group E4 supplemented with Mycostop Duplo® adsorbent in amount of 2.5kg/t of feed. All diets were formulated to be isocaloric and isonitrogenous. The results revealed significant improvements in productive performance parameters, including average daily gain (ADG), average daily feed intake (ADFI), and feed conversion ratio (FCR), in piglets fed diets containing mycotoxin adsorbents. Serum enzyme activities were also assessed to gauge the impact of mycotoxin adsorbents on piglets' health. The activities of liver enzymes aspartate transaminase (AST), gamma-glutamyltransferase (GGT), and gut health-related enzymes (amylase and lipase) were evaluated. Piglets consuming diets supplemented with mycotoxin adsorbents exhibited a reduction in the activities of liver enzymes, indicating lower hepatic stress, and an enhancement in the activity of gut health-related enzymes, reflecting improved nutrient digestion and absorption. In conclusion, the inclusion of mycotoxin adsorbents in piglet diets resulted in significant improvements in productive performance and serum enzyme activities.