Published in
Royal Society of Chemistry, RSC Chemical Biology, 10(4), p. 794-803, 2023
DOI: 10.1039/d3cb00122a
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Bind&Bite: covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins
Journal article published in 2023 by
Jannis Beutel 
,
Pierre Tannig,
Riccardo Di Vincenzo ,
Thomas Schumacher,
Klaus Überla ,
Jutta Eichler
,
Pierre Tannig,
Riccardo Di Vincenzo ,
Thomas Schumacher,
Klaus Überla ,
Jutta Eichler
This paper is made freely available by the publisher.
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Abstract
A pair of heterodimeric coiled-coil peptides was modified to enable covalent stabilization of the dimer without using enzymes or cysteine. Fusion of the peptides to a protein and a chemical moiety, respectively, facilitates site-selective protein modification.