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BioScientifica, Journal of Molecular Endocrinology, 1(50), p. R11-R19, 2012

DOI: 10.1530/jme-12-0203

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The emerging role of the mitochondrial-derived peptide humanin in stress resistance

Journal article published in 2012 by Kelvin Yen ORCID, Changhan Lee, Hemal H. Mehta, Pinchas Cohen
This paper is available in a repository.
This paper is available in a repository.

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Abstract

The discovery of humanin, a novel, mitochondrial-derived peptide, has created a potentially new category of biologically active peptide. As more research unravels the endogenous role of humanin as well as its potential pharmacological use, its role in stress resistance has become clearer. Humanin protects cells from oxidative stress, serum starvation, hypoxia, and other insults in vitro and also improves cardiovascular disease as well as Alzheimer's disease in vivo. In this review, we discuss the emerging role of humanin in stress resistance and its proposed mechanism of action.