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Public Library of Science, PLoS ONE, 9(9), p. e109046, 2014

DOI: 10.1371/journal.pone.0109046

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Chimeric NP Non Coding Regions between Type A and C Influenza Viruses Reveal Their Role in Translation Regulation

Journal article published in 2014 by Bernadette Crescenzo-Chaigne, Cyril Barbezange ORCID, Vianney Frigard, Damien Poulain, Sylvie van der Werf
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Exchange of the non coding regions of the NP segment between type A and C influenza viruses was used to demonstrate the importance not only of the proximal panhandle, but also of the initial distal panhandle strength in type specificity. Both elements were found to be compulsory to rescue infectious virus by reverse genetics systems. Interestingly, in type A influenza virus infectious context, the length of the NP segment 5′ NC region once transcribed into mRNA was found to impact its translation, and the level of produced NP protein consequently affected the level of viral genome replication.