Published in
American Society for Microbiology, Microbiology Spectrum, 3(11), 2023
DOI: 10.1128/spectrum.01066-23
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A Mycobacterium tuberculosis Effector Targets Mitochondrion, Controls Energy Metabolism, and Limits Cytochrome c Exit
Journal article published in 2023 by
Marianne Martin,
Angelique deVisch,
Yves-Marie Boudehen,
Philippe Barthe 
,
Claude Gutierrez,
Obolbek Turapov,
Talip Aydogan,
Laurène Heriaud,
Jerome Gracy,
Olivier Neyrolles ,
Galina V. Mukamolova ,
François Letourneur ,
Martin Cohen-Gonsaud
,
Claude Gutierrez,
Obolbek Turapov,
Talip Aydogan,
Laurène Heriaud,
Jerome Gracy,
Olivier Neyrolles ,
Galina V. Mukamolova ,
François Letourneur ,
Martin Cohen-Gonsaud
This paper is made freely available by the publisher.
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Abstract
In this article, using a combination of techniques (bioinformatics, structural biology, and cell biology), we identified and characterized a new class of effectors present only in intracellular mycobacteria. These proteins specifically target host cell mitochondria when ectopically expressed in cells.