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American Chemical Society, Nano Letters, 1(6), p. 1-6, 2005

DOI: 10.1021/nl051935m

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Quantum dots with a paramagnetic coating as a bimodal molecular imaging probe

Journal article published in 2006 by Willem J. M. Mulder, Wjm Willem Mulder, Rolf Koole, Ricardo J. Brandwijk, Rj Ricardo Brandwijk, Gert Storm, Ptk Patrick Chin, Patrick T. K. Chin, Gustav J. Strijkers ORCID, Gj Gustav Strijkers, C. D. Donega, Celso de Mello Donegá ORCID, C. Celso de Mello Donegá, K. Klaas Nicolaij, Klaas Nicolay and other authors.
This paper is available in a repository.
This paper is available in a repository.

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Abstract

MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r(1), of nearly 2000 mM(-1)s(-1) per quantum dot. The quantum dots were functionalized by covalently linking alpha v/beta 3-specific RGD peptides, and the specificity was assessed and confirmed on cultured endothelial cells. The bimodal character, the high relaxivity, and the specificity of this nanoparticulate probe make it an excellent contrast agent for molecular imaging purposes.