Published in
Royal Society of Chemistry, RSC Advances, 31(13), p. 21153-21162, 2023
DOI: 10.1039/d3ra02916f
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Design, synthesis, in silico, and in vitro evaluation of benzylbenzimidazolone derivatives as potential drugs on α-glucosidase and glucokinase as pharmacological targets
Journal article published in 2023 by
Cress Lumadhar Santos-Ballardo 
,
Julio Montes-Ávila ,
José Guadalupe Rendon-Maldonado ,
Rosalio Ramos-Payan ,
Sarita Montaño ,
Juan I. Sarmiento-Sánchez,
Selene de Jesús Acosta-Cota ,
Adrián Ochoa-Terán ,
Pedro de Jesús Bastidas-Bastidas ,
Ulises Osuna-Martínez
,
Julio Montes-Ávila ,
José Guadalupe Rendon-Maldonado ,
Rosalio Ramos-Payan ,
Sarita Montaño ,
Juan I. Sarmiento-Sánchez,
Selene de Jesús Acosta-Cota ,
Adrián Ochoa-Terán ,
Pedro de Jesús Bastidas-Bastidas ,
Ulises Osuna-Martínez
This paper is made freely available by the publisher.
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Abstract
An in silico assay was designed, and generated compounds were studied to delimitate the synthesis by microwave irradiation–conventional heat combination. In vitro evaluation as antihyperglycemic and hypoglycemic agents were made, where 2s has good potential.