Intimate partner violence (IPV) is a serious social issue that has impact on the physical and psychological well-being of victims. Exploring the mechanisms that intervene in the intergenerational transmission of violence from family of origin (VFO) to couple relationships can provide theoretical and clinical data. Drawing on the attachment theory and Fonagy’s mentalizing model, this article aims to explore the relationship between VFO and IPV perpetration and the mediating role of mentalization. A total of 531 Italian participants who were in a relationship (68.7% females; mean age = 28.1, standard deviation = 9.0) participated anonymously in the study by completing an online questionnaire. A direct association emerged between VFO and mentalization and between VFO and IPV. Furthermore, mentalization demonstrated a direct association with IPV. An indirect effect was also found between VFO and IPV with the mediation of mentalization. However, the indirect effect of VFO on IPV through mentalization was significant only in relation to psychological IPV, whereas it was not supported in relation to physical and sexual IPV. Although further research is needed across different populations, forms, and typologies of IPV, the preliminary results found the role of mentalization in psychological IPV, providing theoretical and clinical insights.