Filter masks are disposable devices intended to be worn in order to reduce exposure to potentially harmful foreign agents of 0.1–10.0 microns. However, to perform their function correctly, these devices should be replaced after a few hours of use. Because of this, billions of non-biodegradable face masks are globally discarded every month (3 million/minute). The frequent renewal of masks, together with the strong environmental impact of non-biodegradable plastic-based mask materials, highlights the need to find a solution to this emerging ecological problem. One way to reduce the environmental impact of masks, decrease their turnover, and, at the same time, increase their safety level is to make them able to inhibit pathogen proliferation and vitality by adding antibacterial materials such as silver, copper, zinc, and graphene. Among these, silver and copper are the most widely used. In this study, with the aim of improving commercial devices’ efficacy and eco-sustainability, Ag-based and Cu-based antibacterial treatments were performed and characterized from morphological, compositional, chemical–physical, and microbiological points of view over time and compared with the antibacterial treatments of selected commercial products. The results demonstrated the good distribution of silver and copper particles onto the surface of the masks, along with almost 100% antibacterial capabilities of the coatings against both Gram-positive and Gram-negative bacteria, which were still confirmed even after several washing cycles, thus indicating the good potential of the developed prototypes for mask application.