Published in
American Society for Microbiology, Microbiology Spectrum, 3(11), 2023
DOI: 10.1128/spectrum.00296-23
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Small Molecule Inhibition of an Exopolysaccharide Modification Enzyme is a Viable Strategy To Block Pseudomonas aeruginosa Pel Biofilm Formation
Journal article published in 2023 by
Erum Razvi 
,
Benjamin R. DiFrancesco,
Gregory A. Wasney,
Zachary A. Morrison,
John Tam,
Anick Auger,
Perrin Baker,
Noor Alnabelseya,
Jacquelyn D. Rich,
Piyanka Sivarajah,
Gregory B. Whitfield,
Joe J. Harrison ,
Roman A. Melnyk ,
Mark Nitz,
P. Lynne Howell
,
Benjamin R. DiFrancesco,
Gregory A. Wasney,
Zachary A. Morrison,
John Tam,
Anick Auger,
Perrin Baker,
Noor Alnabelseya,
Jacquelyn D. Rich,
Piyanka Sivarajah,
Gregory B. Whitfield,
Joe J. Harrison ,
Roman A. Melnyk ,
Mark Nitz,
P. Lynne Howell
This paper is made freely available by the publisher.
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Abstract
Present in more than 500 diverse Gram-negative and 900 Gram-positive organisms, the Pel polysaccharide is one of the most phylogenetically widespread biofilm matrix determinants found to date. Partial de- N -acetylation of this α-1,4 linked N -acetylgalactosamine polymer by the carbohydrate modification enzyme PelA is required for Pel-dependent biofilm formation in Pseudomonas aeruginosa and Bacillus cereus .