Published in
Royal Society of Chemistry, Chemical Science, 39(14), p. 10800-10805, 2023
DOI: 10.1039/d3sc04083f
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A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction
Journal article published in 2023 by
Jessica Iegre 
,
Sona Krajcovicova ,
Anders Gunnarsson,
Lisa Wissler,
Helena Käck ,
Anna Luchniak,
Stefan Tångefjord ,
Frank Narjes ,
David R. Spring
,
Sona Krajcovicova ,
Anders Gunnarsson,
Lisa Wissler,
Helena Käck ,
Anna Luchniak,
Stefan Tångefjord ,
Frank Narjes ,
David R. Spring
This paper is made freely available by the publisher.
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Abstract
Application of DVP stapling methodology to efficiently develop Nrf2 peptides with nM activity in enzymatic assays, submicromolar activity in cells and non-cytotoxicity, characterised by high resolution X-ray co-crystallography.