Preview Eryptosis is the programmed cell death of red blood cells (RBCs) in response to different kinds of stress. Several hallmarks of eryptosis have been determined over the years, including increased calcium influx, phosphatidylserine (PS) externalisation, cell shrinkage, and membrane vesiculation1. Even though medically-induced eryptosis (such as the interventional experiments reported in this issue or during RBC aging under blood bank conditions) may differ compared to the aging processes in vivo, some molecular signalling pathways are thought to be common2. As such, the study of stored RBCs under various physiological cell stressors could offer mechanistic insight into the life and death of RBCs in vivo, in health and disease. At the same time, metabolomics constitutes an advanced research tool to perform high throughput analysis of energy metabolism in RBCs. [ … ]