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Royal Society of Chemistry, Chemical Science, 2024

DOI: 10.1039/d4sc01976h

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Picking the tyrosine-lock: chemical synthesis of the tyrosyl-DNA phosphodiesterase I inhibitor recifin A and analogues

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Chemical synthesis of the peptide recifin A reveals insights into its unique structure and interaction with the cancer target TDP1.