Quality of Life (QoL) is a multifaceted concept encompassing economic, social, environmental, psychological, and physical dimensions of an individual’s life, including personal living conditions, happiness, well-being, and life satisfaction. As a vital criterion for sustainable development and active social policy in countries, QoL has been significantly influenced by the dynamic technological evolution of social media. However, the comprehensive impact of social media, including its role in disseminating disinformation – a major social and socio-economic concern – on QoL remains underexplored. This research aims to develop a novel fuzzy model to assess the level of disinformation on digital platforms and its correlation with the population’s QoL. Employing a mathematical approach rooted in expert evaluation, this study leverages intellectual knowledge analysis and fuzzy set theory. Grounded in data from real respondents and knowledge-based models, this study pioneers an information model to evaluate inhabitants’ QoL, incorporating factors such as financial concerns, perception of disinformation, and its influence on digital platforms. The fuzzy estimation model, verified with data from 3,036 respondents, quantitatively assesses citizens’ QoL. An illustrative application of the model demonstrates its effectiveness. The findings are particularly valuable for policymakers, experts in economic and innovative development, aiding the creation of regulatory and monitoring mechanisms to foster sustainable economic growth and devise effective development strategies.